cannabinoid

Cannabidiol exerts sebostatic and antiinflammatory effects on human sebocytes

ABSTRACT We additionally found that CBD also prevented the “pro-acne” LA-T combination from elevating the expression of TNFA (Figure ​3A), a key cytokine in the pathogenesis of acne vulgaris (2, 24–30). These data suggested that CBD may exert antiinflammatory actions on human sebocytes (as had already been demonstrated for CBD in several other experimental models, …

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The gastrointestinal tract – a central organ of cannabinoid signaling in health and disease

ABSTRACT From animal studies it was rightfully concluded that cannabinoid agonists could improve visceral pain thresholds in humans. In a previous study performed in healthy volunteers to investigate the effect of dronabinol (Δ9-THC) on colonic motility and sensation, 7.5 mg dronabinol induced relaxation of colon motility and tone postprandially (72). The effect of dronabinol on …

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