neuropathic pain

The Therapeutic Potential of Cannabis and Cannabinoids

ABSTRACT Cannabis-based medications exert their effects mainly through the activation of cannabinoid receptors (CB1 and CB2). More than 100 controlled clinical trials of cannabinoids or whole-plant preparations for various indications have been conducted since 1975. The findings of these trials have led to the approval of cannabis-based medicines (dronabinol, nabilone, and a cannabis extract [THC:CBD=1:1]) …

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HIV & AIDS: Cannabinoids and CBD Research Overview

ABSTRACT While the side effects of HIV and AIDS treatments can impinge on one’s life quality, studies have shown that medical cannabis can help make the adverse effects more manageable. HIV positive patients consuming medical Cannabis have reported significant improvements in appetite, muscle pain levels, nausea, anxiety, depression, and skin tingling. Studies have found that …

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Joints for joints: cannabinoids in the treatment of rheumatoid arthritis.

ABSTRACT Peripherally, cannabinoids show anti-inflammatory effects by activating cannabinoid type 2 receptors (CB2) which decrease cytokine production and immune cell mobilization. In contrast, cannabinoid type 1 receptor (CB1) activation on immune cells is proinflammatory while CB1 antagonism provides anti-inflammatory effects by increasing β2-adrenergic signaling in the joint and secondary lymphoid organs. In addition, the nonpsychotropic …

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