ms

Cannabinoids for Treatment of MS Symptoms: State of the Evidence.

ABSTRACT Two recent high-quality systematic reviews concluded that the only strong evidence for medical marijuana in neurological disorders was for reducing the symptoms of patient-reported spasticity and central pain in MS and that the only complementary and alternative medicine (CAM) intervention in MS with strong supportive evidence was cannabinoids. Based on this review, they concluded …

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The Therapeutic Potential of Cannabis and Cannabinoids

ABSTRACT Cannabis-based medications exert their effects mainly through the activation of cannabinoid receptors (CB1 and CB2). More than 100 controlled clinical trials of cannabinoids or whole-plant preparations for various indications have been conducted since 1975. The findings of these trials have led to the approval of cannabis-based medicines (dronabinol, nabilone, and a cannabis extract [THC:CBD=1:1]) …

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Cannabis for Multiple Sclerosis: Prescriber’s Perspective

ABSTRACT A 2018 systematic review examined randomized controlled trials pertaining to the symptoms with the strongest evidence base, including 2 that are relevant to MS: pain and spasticity.4 The authors found that patients taking cannabinoids were more likely to achieve pain reduction of at least 30%, with a risk ratio of 1.37 (95% CI, 1.14-1.64) …

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Cannabidiol to Improve Mobility in People with Multiple Sclerosis

ABSTRACT The cannabis plant contains many biologically active chemicals, including ~60 cannabinoids (3). Cannabidiol (CBD) and Δ9-tetrahydrocannabinol (THC) are typically the most concentrated chemical components of cannabis and believed to primarily drive therapeutic benefit. There is evidence that CBD has a number of beneficial pharmacological effects (4, 5). It is anti-inflammatory, antioxidative, antiemetic, antipsychotic, and …

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