lennox-gastaut

Managing drug-resistant epilepsy: challenges and solutions

ABSTRACT To date, there are restricted data assessing chronic models of epilepsy as well as animal models of epileptogenesis. Some clinical evidence indicates that CBD is able to manage epilepsy in adults and children affected by refractory seizures, with a favorable side effect profile. Tzadok et al treated 74 pediatric patients, who were resistant to …

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Could Cannabidiol be a Treatment Option for Intractable Childhood and Adolescent Epilepsy?

ABSTRACT Some U.S. states now allow the use of cannabis for medical treatment. Many patients with epilepsy have wanted to try cannabis as a treatment even though preclinical and clinical evidence is limited. As mentioned above, several clinical studies have investigated CBD after the late 19th century. Recent studies have shown an effect of CBD …

Could Cannabidiol be a Treatment Option for Intractable Childhood and Adolescent Epilepsy? Read More »

Cannabidiol: A New Hope for Patients With Dravet or Lennox-Gastaut Syndromes

ABSTRACT Pure, plant-based CBD is a pharmaceutical grade extract that exhibits clinically significant antiseizure properties, with a hypothesized multimodal mechanism of action. In the GWPCARE trial series, CBD displayed superior efficacy in reducing key seizure frequencies (convulsive seizures in DS; drop seizures in LGS) by 17% to 23% compared with placebo as adjunctive therapy to …

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