inflammatory illness

The gastrointestinal tract – a central organ of cannabinoid signaling in health and disease

ABSTRACT From animal studies it was rightfully concluded that cannabinoid agonists could improve visceral pain thresholds in humans. In a previous study performed in healthy volunteers to investigate the effect of dronabinol (Δ9-THC) on colonic motility and sensation, 7.5 mg dronabinol induced relaxation of colon motility and tone postprandially (72). The effect of dronabinol on …

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Cannabinoids for treating inflammatory bowel diseases: where are we and where do we go?

ABSTRACT Experimental evidence gathered from preclinical IBD models and conducted in rodents point to a strong potential of the ECS components to serve as drug targets in inflammatory diseases of the intestine. Data suggest a homeostatic role of the ECS in the gut. Accordingly, it is believed that the enhancement of endocannabinoid signaling, as observed …

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