endocannabinoid

Cannabinoids inhibit human keratinocyte proliferation through a non-CB1/CB2 mechanism and have a potential therapeutic value in the treatment of psoriasis.

ABSTRACT The results indicate that while CB receptors may have a circumstantial role in keratinocyte proliferation, they do not contribute significantly to this process. Our results show that cannabinoids inhibit keratinocyte proliferation, and therefore support a potential role for cannabinoids in the treatment of psoriasis. SOURCE

Cannabis sativa L. and Nonpsychoactive Cannabinoids: Their Chemistry and Role against Oxidative Stress, Inflammation, and Cancer

ABSTRACT By focusing the attention on hemp nonpsychoactive cannabinoids, CBD has been demonstrated to be useful in the treatment of different inflammatory ailments, including bowel diseases (e.g., Crohn’s and ulcerative colitis), neuronal diseases (e.g., Parkinson and Alzheimer), and a wide range of inflammatory skin diseases (e.g., atopic dermatitis and psoriasis) [21]. SOURCE

The gastrointestinal tract – a central organ of cannabinoid signaling in health and disease

ABSTRACT From animal studies it was rightfully concluded that cannabinoid agonists could improve visceral pain thresholds in humans. In a previous study performed in healthy volunteers to investigate the effect of dronabinol (Δ9-THC) on colonic motility and sensation, 7.5 mg dronabinol induced relaxation of colon motility and tone postprandially (72). The effect of dronabinol on …

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