Cannabinoid Signaling in the Skin: Therapeutic Potential of the “C(ut)annabinoid” System

ABSTRACT

This concept was further supported by a small, single-blind, split-face study, in which a cream containing 3% Cannabis seed extract was applied twice daily to the cheeks of patients for 12 weeks. The treatment was found to be efficient in reducing sebum production and erythema compared to the vehicle treated side [124]. Moreover, a synthetic CBD containing special topical formulation (“BTX 1503”) exhibited promising anti-acne potential in a small phase Ib clinical trial [125], and its efficacy is now being tested in a randomized, double-blind, vehicle-controlled phase II clinical study (ClinicalTrials.gov ID: NCT03573518).

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