The endocannabinoid system of the skin in health and disease: novel perspectives and therapeutic opportunities

ABSTRACT

Topical formulations that contain cannabinoid ligands (or that enhance the cutaneous ECS tone) could have therapeutic values in skin inflammations. Indeed, recently, a new drug containing PEA has been approved by the FDA for the treatment of dermatitis [70]. Moreover, a recent pilot study on 20 pediatric patients suffering from atopic dermatitis aimed to assess the efficacy and safety of the twice daily application of a topical emulsion containing 2% adelmidrol, a PEA analog. Excitingly, this study showed an 80% increase in symptom resolution [70,71].

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