To date, there are restricted data assessing chronic models of epilepsy as well as animal models of epileptogenesis. Some clinical evidence indicates that CBD is able to manage epilepsy in adults and children affected by refractory seizures, with a favorable side effect profile. Tzadok et al treated 74 pediatric patients, who were resistant to more than seven AEDs, with medical cannabis oil. The results were highly promising, with 89% of patients reporting a reduction in seizure frequency. Conversely, seizure exacerbation after cannabis use has also been observed, and in this same study, 7% of patients reported this, leading to CBD withdrawal.